Resource Type

Journal Article 385

Conference Videos 8

Year

2024 1

2023 23

2022 36

2021 42

2020 27

2019 30

2018 17

2017 18

2016 31

2015 14

2014 14

2013 17

2012 10

2011 22

2010 19

2009 22

2008 11

2007 15

2006 2

2005 1

open ︾

Keywords

natural gas 19

Software-defined networking (SDN) 4

China 3

invasion 3

mesenchymal stem cells 3

natural frequency 3

CAR T cells 2

Cancer 2

Controller placement 2

Natural language processing 2

Stem cells 2

cancer immunotherapy 2

carbon-based fuels 2

embryonic stem cells 2

energy consumption 2

environmental protection 2

fuel cells 2

genetic modification 2

immunotherapy 2

open ︾

Search scope:

排序： Display mode:

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicactivation, well known for its role in the immune surveillance against tumor and pathogen-infected cellsIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

HTML PDF Collect

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract: Compelling evidence suggests that NK cells play a critical role in the immune function of the liver andTo obtain comprehensive insights into the putative influence of NK cells on HCC, this paper summarizescurrent knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

HTML PDF Collect

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract:

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigensNatural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolicIn this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitiskiller T cells during the progression of liver diseases, which might be caused by changes in naturalkiller T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

HTML PDF Collect

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: Natural killer (NK) cells, a type of cytotoxic lymphocytes, can infiltrate into ischemic brain and exacerbateThis study investigated the effects of ASIV on post-ischemic brain infiltration and activation of NK cellsAbundant NK cells infiltrated into the ischemic hemisphere on day 1 after brain ischemia, and this infiltration

Keywords： astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factor-κB    

HTML PDF Collect

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract:

Natural killer (NK) cells are considered to be critical players in anticancer immunity.However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells, expanding allogeneic NK cells, usage of stable allogeneic NK cell lines and genetically modifying freshNK cells or NK cell lines.In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

HTML PDF Collect

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidlyand directly kill transformed cells in the absence of antigen presensitization.Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK celllines, have been used for producing NK cells.In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

HTML Collect

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer(BAK) cells, and the effect of anticancer BAK cells was studied.BAK cells have the ability to kill bladder tumor cells, and the antitumor activity of effecter cellsThe result of LDH release assay showed that the antitumor activity of BAK cells stimulated by Recombinant

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

HTML PDF Collect

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract:

Natural killer (NK) cells are key innate immune cells that provide the first line of defense againstAlthough NK cells can discriminate between "self" and "non-self," recognize abnormalcells, and eliminate transformed cells and malignancies in real time, tumors develop several strategiesNK cells, umbilical cord blood (UCB) or induced pluripotent stem cell (iPSC)-derived NK cells, memory-likeNK cells, and NK cell line NK-92 cells, for the treatment of different types of tumors.

Keywords： Natural killer cell     Immunotherapy     Cancer     Clinical trial     Chimeric antigen receptor    

HTML PDF Collect

Research on the theory and application of adsorbed natural gas used in new energy vehicles: A review

Zhengwei NIE,Yuyi LIN,Xiaoyi JIN

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 3,   Pages 258-274 doi: 10.1007/s11465-016-0381-2

Abstract:

Natural gas, whose primary constituent is methane, has been considered a convincing alternative forAdsorbed natural gas (ANG), the most promising methane storage method, has been an active field of studyANG constitutes a safe and low-cost way to store methane for natural gas vehicles at an acceptable energy

Keywords： adsorbed natural gas (ANG)     adsorbent     adsorption theory     conformable tank     natural gas vehicles (NGVs)    

HTML PDF Collect

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

HTML PDF Collect

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
HTML PDF Collect

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: During natural infection, viral replication is initially controlled by innate immunity before adaptiveimmune responses (T cells and antibody-producing B cells) achieve viral clearance and host recovery.Recent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

HTML PDF Collect

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

HTML PDF Collect

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

HTML PDF Collect

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveWith the rapid advances in genome-editing and cloning using homologously recombined somatic cells, theneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells

Keywords： bovine     embryonic     induced     pluripotent stem cells    

HTML PDF Collect

Title Author Date Type Operation

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Research on the theory and application of adsorbed natural gas used in new energy vehicles: A review

Zhengwei NIE,Yuyi LIN,Xiaoyi JIN

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article